. Physical diagnosis . Fig. 245.—Nucleated Red Cells, m, m,Megaloblasts; n, normoblast; s, stippledcell. THE BLOOD 443 cell may be mistaken for a leucocyte. The mistake may be avoided,however, after some experience. In the protoplasm of nucleated cellsthere are often concentric rings like the layers in an oyster shell, andtheir outline is usually more irregular than that of any leucocyte.Further points of differentiation must be learned by practice. 2. Leucocytes.—In normal blood four main varieties may be dis-tinguished : (a) Polynuclears or polymorphonuclear neutrophiles. (b) Lymphocytes (la

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. Physical diagnosis . Fig. 245.—Nucleated Red Cells, m, m, Megaloblasts; n, normoblast; s, stippledcell. THE BLOOD 443 cell may be mistaken for a leucocyte. The mistake may be avoided, however, after some experience. In the protoplasm of nucleated cellsthere are often concentric rings like the layers in an oyster shell, andtheir outline is usually more irregular than that of any leucocyte.Further points of differentiation must be learned by practice. 2. Leucocytes.—In normal blood four main varieties may be dis-tinguished : (a) Polynuclears or polymorphonuclear neutrophiles. (b) Lymphocytes (large and small). (c) Eosinophiles. (d) Mast cells. (a) Polynuclears.—The deeply stained, markedly contorted nucleusassumes a great variety of shapes in different cells, and is surroundedby a pinkish protoplasm studded with spots or granules just large.