Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor

The maturation factor is approximately how long (in days) it takes a reticulocyte to transform into a RBC once released in the peripheral blood at a particular degree of anemia.



Hypoproliferative (i.e. bone marrow not responding appropriately)- Retic Index < 2:

 • Anemia of chronic inflammation

 • Nutrient deficiencies: Iron deficiency (including chronic blood loss), Vitamin B12, Folate

 • Hormone deficiencies: Chronic kidney disease, Hypothyroidism, Hypogonadism

 • Bone marrow failure: Aplastic anemia, Marrow infiltration (e.g. cancer, infection), Marrow suppression (e.g. drugs, chemotherapy, radiation)

 • "Hospital-acquired anemia"

Hyperproliferative (i.e. bone marrow responding appropriately) - Retic Index > 3:

 • Acute blood loss: Trauma, Gl bleed, Retroperitoneal, Uterine

 • Hemolysis: Autoimmune, Microangiopathic hemolytic anemia, Intrinsic RBC defects (e.g. sickle cell anemia, G6PD deficiency), Infections, Hypersplenism



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/



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